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CJD Prions a Surgery Risk?

By Joan Stephenson, PhD

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rilization procedures routinely used for surgical implements do not destroy prions (N Engl J Med. 2003;349:1812-1820).

Using an extremely sensitive prion detection method, the researchers examined brain tissue and extraneural organs of 36 patients with sporadic CJD. In addition to detecting prions in the brain tissue of all patients, they found prions in 10 of 28 spleen specimens and in 8 of 22 samples of skeletal muscles.

Neurological examinations of patients in the prodromal stages of sporadic CJD often include electromyography and muscle biopsies. Thus, the researchers said, finding prions in skeletal muscle of patients with the disorder "reinforces calls for the use of single-use needle electrodes and of special protocols for the sterilization of surgical instruments used for biopsies."

The article this news story refers to was published in the New England Journal of Medicine, vol. 349, pages1812-1820

Joan Stephenson

Joan Stephenson, PhD

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